Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy.
Identifieur interne : 000C48 ( Main/Exploration ); précédent : 000C47; suivant : 000C49Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy.
Auteurs : Mija Marinkovi [Croatie] ; Matilda Šprung [Croatie] ; Maja Buljubaši [Croatie] ; Ivana Novak [Croatie]Source :
- Oxidative medicine and cellular longevity [ 1942-0994 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Tumeurs.
- physiologie : Autophagie.
- Animaux, Humains, Tumeurs.
English descriptors
- KwdEn :
- MESH :
Abstract
In the last two decades, accumulating evidence pointed to the importance of autophagy in various human diseases. As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes. Both autophagy upregulation and downregulation have been found in cancers, suggesting its dual oncogenic and tumor suppressor properties during malignant transformation. Identification of the key autophagy targets is essential for the development of new therapeutic agents. Despite this great potential, no therapies are currently available that specifically focus on autophagy modulation. Although drugs like rapamycin, chloroquine, hydroxychloroquine, and others act as autophagy modulators, they were not originally developed for this purpose. Thus, autophagy may represent a new and promising pharmacologic target for future drug development and therapeutic applications in human diseases. Here, we summarize our current knowledge in regard to the interplay between autophagy and malignancy in the most significant tumor types: pancreatic, breast, hepatocellular, colorectal, and lung cancer, which have been studied in respect to autophagy manipulation as a promising therapeutic strategy. Finally, we present an overview of the most recent advances in therapeutic strategies involving autophagy modulators in cancer.
DOI: 10.1155/2018/8023821
PubMed: 29643976
Affiliations:
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xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Science, University of Split, Ruđera Boškovića 33, 21000 Split</wicri:regionArea><wicri:noRegion>21000 Split</wicri:noRegion></affiliation></author><author><name sortKey="Buljubasi, Maja" sort="Buljubasi, Maja" uniqKey="Buljubasi M" first="Maja" last="Buljubaši">Maja Buljubaši</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>School of Medicine, University of Split, Šoltanska 2, 21000 Split</wicri:regionArea><wicri:noRegion>21000 Split</wicri:noRegion></affiliation></author><author><name sortKey="Novak, Ivana" sort="Novak, Ivana" uniqKey="Novak I" first="Ivana" last="Novak">Ivana Novak</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia.</nlm:affiliation><country 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As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes. Both autophagy upregulation and downregulation have been found in cancers, suggesting its dual oncogenic and tumor suppressor properties during malignant transformation. Identification of the key autophagy targets is essential for the development of new therapeutic agents. Despite this great potential, no therapies are currently available that specifically focus on autophagy modulation. Although drugs like rapamycin, chloroquine, hydroxychloroquine, and others act as autophagy modulators, they were not originally developed for this purpose. Thus, autophagy may represent a new and promising pharmacologic target for future drug development and therapeutic applications in human diseases. Here, we summarize our current knowledge in regard to the interplay between autophagy and malignancy in the most significant tumor types: pancreatic, breast, hepatocellular, colorectal, and lung cancer, which have been studied in respect to autophagy manipulation as a promising therapeutic strategy. Finally, we present an overview of the most recent advances in therapeutic strategies involving autophagy modulators in cancer.</div></front></TEI><affiliations><list><country><li>Croatie</li></country></list><tree><country name="Croatie"><noRegion><name sortKey="Marinkovi, Mija" sort="Marinkovi, Mija" uniqKey="Marinkovi M" first="Mija" last="Marinkovi">Mija Marinkovi</name></noRegion><name sortKey="Buljubasi, Maja" sort="Buljubasi, Maja" uniqKey="Buljubasi M" first="Maja" last="Buljubaši">Maja Buljubaši</name><name sortKey="Novak, Ivana" sort="Novak, Ivana" uniqKey="Novak I" first="Ivana" last="Novak">Ivana Novak</name><name sortKey="Sprung, Matilda" sort="Sprung, Matilda" uniqKey="Sprung M" first="Matilda" last="Šprung">Matilda Šprung</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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